diff --git a/keymapper/getdevices.py b/keymapper/getdevices.py
index 95d7890c..6bb69382 100644
--- a/keymapper/getdevices.py
+++ b/keymapper/getdevices.py
@@ -22,6 +22,7 @@
 """Device and evdev stuff that is independent from the display server."""
 
 
+import re
 import multiprocessing
 import threading
 import time
@@ -168,6 +169,28 @@ def classify(device):
     return UNKNOWN
 
 
+DENYLIST = [
+    ('Yubico', r'.*YubiKey.*')
+]
+
+
+def is_denylisted(device):
+    """Check if a device should not be used in key-mapper.
+
+    Parameters
+    ----------
+    device : InputDevice
+    """
+    for vendor, name in DENYLIST:
+        if not re.match(vendor, str(device.info.vendor), re.IGNORECASE):
+            return False
+
+        if not re.match(name, str(device.name), re.IGNORECASE):
+            return False
+
+    return True
+
+
 class _GetDevices(threading.Thread):
     """Process to get the devices that can be worked with.
 
@@ -217,6 +240,9 @@ class _GetDevices(threading.Thread):
                 # skip devices that don't provide buttons that can be mapped
                 continue
 
+            if is_denylisted(device):
+                continue
+
             name = device.name
             path = device.path
 
diff --git a/tests/test.py b/tests/test.py
index 31a052ad..00723e7b 100644
--- a/tests/test.py
+++ b/tests/test.py
@@ -212,6 +212,14 @@ fixtures = {
         'info': evdev.device.DeviceInfo(5, 1, 5, 1),
         'name': 'key-mapper device 2'
     },
+
+    # denylisted
+    '/dev/input/event51': {
+        'capabilities': {evdev.ecodes.EV_KEY: keyboard_keys},
+        'phys': 'usb-0000:03:00.0-5/input1',
+        'info': evdev.device.DeviceInfo(6, 'YuBiCo', 6, 1),
+        'name': 'fooYuBiKeYbar'
+    },
 }